Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Hong-Xiang LiuCharlotte M Mistretta

Abstract

Fungiform papillae are epithelial taste organs that form on the tongue, requiring differentiation of papillae and inter-papilla epithelium. We tested roles of epidermal growth factor (EGF) and the receptor EGFR in papilla development. Developmentally, EGF was localized within and between papillae whereas EGFR was progressively restricted to inter-papilla epithelium. In tongue cultures, EGF decreased papillae and increased cell proliferation in inter-papilla epithelium in a concentration-dependent manner, whereas EGFR inhibitor increased and fused papillae. EGF preincubation could over-ride disruption of Shh signaling that ordinarily would effect a doubling of fungiform papillae. With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown. Thus, EGF/EGFR signaling by means of PI3K/Akt, MEK/ERK, and p38 MAPK contributes to epithelial cell proliferation between papillae; this biases against papilla differentiation and reduces numbers of papillae.

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Citations

Nov 30, 2013·Chemical Senses·Pu FengHong Wang
Aug 19, 2009·Annals of the New York Academy of Sciences·Shoba Thirumangalathu, Linda A Barlow
Jan 4, 2012·Journal of Neuroscience Research·Liqiao ShiLynnette Phillips McCluskey
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May 17, 2017·Development·Michaela ProchazkovaOphir D Klein
Oct 2, 2019·Genesis : the Journal of Genetics and Development·Mohamed IshanHong-Xiang Liu
Feb 14, 2017·Annual Review of Physiology·Charlotte M Mistretta, Archana Kumari
Aug 19, 2009·Annals of the New York Academy of Sciences·Hong-Xiang LiuCharlotte M Mistretta
Aug 24, 2017·Scientific Reports·Xiaogang CuiHong-Xiang Liu
Mar 20, 2019·International Journal of Molecular Sciences·Charlotte M Mistretta, Archana Kumari
Feb 8, 2018·PLoS Genetics·Yumei QinRobert F Margolskee

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