Fungitoxic activity of saponins: practical use and fundamental principles

Advances in Experimental Medicine and Biology
K Gruiz

Abstract

Saponins, as aescin or alfalfa saponins have fungistatic activity on Trichoderma viride G fungal strain. (Biacs and Gruiz, 1982) The principle of fungistatic activity is an interaction between saponin and membrane constituents, such as sterols, proteins and phospholipids. The interaction results in the destruction of the cell membrane and an increase of the ion permeability (Gruiz and Biacs, 1989). Some Trichoderma strains are sensitive, whereas others are resistant to saponins. Their lipid composition after treatment differs considerably (Biacs and Gruiz, 1984), although ergosterol content of the membrane increased in both sensitive and nonsensitive strains. The possible metabolic changes in fatty acid composition of membrane phospholipids influence sensitivity of fungi to saponins. An important role is attributed to linoleic acid (Gruiz and Biacs, 1989). Since the fungal membrane composition can be changed by exogenously added sterols and fatty acids or triglycerides (Gruiz and Biacs, 1990), experiments were made to decrease saponin sensitivity of Trichoderma viride by giving linoleic-acid-containing oil and ergosterol. In such a way the elimination of the inhibitory effect of saponins was successful. The ergosterol content a...Continue Reading

Citations

Feb 12, 2008·Applied and Environmental Microbiology·Mara FavillaClaudio Altomare
Dec 19, 2019·Frontiers in Plant Science·Lucie TrdáPavel Matušinsky
Jan 29, 2021·Toxicon : Official Journal of the International Society on Toxinology·Madiha ZaynabShuangfei Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.