Furin cleavage sites naturally occur in coronaviruses.

Stem Cell Research
Yiran Wu, Suwen Zhao

Abstract

The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A 12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which raised controversy views on origin of the virus. Here we analyzed the phylogenetic relationships of coronavirus spike proteins and mapped furin recognition motif on the tree. Furin cleavage sites occurred independently for multiple times in the evolution of the coronavirus family, supporting the natural occurring hypothesis of SARS-CoV-2.

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Citations

Apr 1, 2021·Environmental Chemistry Letters·Rossana SegretoDaoyu Zhang
Jun 11, 2021·Nature·Amy Maxmen, Smriti Mallapaty
Jun 24, 2021·Journal of Diabetes Science and Technology·David C KlonoffGuillermo E Umpierrez
Sep 24, 2021·Scientific Reports·Georgina I López-CortésMarco V José
Sep 26, 2021·Microbiology and Immunology·Makoto Takeda

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Software Mentioned

Prime
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MegaX
Schrodinger
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