Furofuran lignans and alkaloids from Clinacanthus nutans

Natural Product Research
Hong-Zhang DiaoChang-Ri Han

Abstract

One new furofuran lignan 2-methoxy-9β-hydroxydiasesamin (1), and four analogues (2-5), together with eight alkaloids (6-13), were isolated from the ethanol extract of the aerial part of Clinacanthus nutans. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All the compounds were isolated from the genus of Clinacanthus for the first time. In addition, lignans isolated from C. nutans was reported for the first time. Compound 1 exhibited modest activity against three human tumor cell lines Hela, MCF-7, and A549, with IC50 values of 68.55, 60.00, and 59.17 μM, respectively.

References

Feb 18, 2005·Natural Product Research·Yun-Sen LiJi-Jun Chen
Feb 19, 2009·Bioorganic & Medicinal Chemistry·Santi SakdaratSasithorn Thongchai
Dec 10, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shu-Fen TuFang-Rong Chang
Apr 18, 2016·Asian Pacific Journal of Tropical Medicine·Ariful AlamZaidul I Sarker

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Methods Mentioned

BETA
NMR
column chromatography

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