PMID: 3917502Jan 1, 1985

Furosemide decreases ventilation in young rabbits

The Journal of Pediatrics
T A Hazinski

Abstract

To test the hypothesis that furosemide would cause metabolic alkalosis and thus alveolar hypoventilation, normal rabbit pups were given either furosemide (4 mg/kg/day) or saline solution for the first 8 to 10 days of life. Pups given furosemide developed primary metabolic alkalosis and reduced ventilation, which resulted in secondary respiratory acidosis. Lung compliance was improved by furosemide, and the ventilatory response to CO2 was unaffected. KCl injection in alkalotic pups increased ventilation and decreased pH. The data show that conventional doses of furosemide can (1) cause metabolic alkalosis and reduce ventilation; (2) increase the PaCO2, which reflects changes in acid-base status and not changes in lung function; and (3) increase lung compliance, perhaps by decreasing lung water. When these effects occur in infants with chronic lung disease, the beneficial effect of furosemide may be obscured.

References

Sep 1, 1978·The Journal of Clinical Investigation·R D BlandM A Bressack
Oct 1, 1973·Clinical Science and Molecular Medicine· Van Ypersele de Strihou, A Frans
Feb 1, 1972·Chest·T M JarboeR G Luke
Mar 1, 1971·The American Journal of Medicine·M A Tuller, F Mehdi
Dec 1, 1983·American Journal of Diseases of Children·P S VenkataramanC C Daugherty
Aug 1, 1983·The Journal of Pediatrics·J Rodriguez-SorianoM J Balzategui
Aug 1, 1980·Respiration Physiology·J T Fisher, J P Mortola
Feb 1, 1956·The Journal of Clinical Investigation·K E ROBERTSH T RANDALL

Citations

Mar 6, 2004·Seminars in Neonatology : SN·Raouf S Amin, Cynthia M Fitton
Jun 1, 1985·The Journal of Pediatrics·E M McCannJ P Brady
Feb 9, 2002·Chest·Folkert BrijkerHans Th M Folgering
Jan 1, 1990·Pediatric Pulmonology·J M DavisJ V Aranda

Related Concepts

Acidosis, Respiratory
Alkalosis
Metazoa
Blood
Carbon Dioxide
Salix - substance
Hydrogen-Ion Concentration
Hypoventilation
Lung Compliance
Chinchilla Rabbits

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