PMID: 6167224Dec 1, 1980Paper

Furosemide, indomethacin and sodium excretion in isolated, blood-perfused dog kidneys

Archives internationales de physiologie et de biochimie
A Nizet

Abstract

Sodium excretion, renal blood flow and glomerular filtration rate were investigated in isolated, blood-perfused dog kidneys, thus excluding the interference of changes in body sodium and water balance. Four groups of experiments were performed : (a) control; (b) blood + indomethacin; (c) blood + furosemide; (d) blood + furosemide and indomethacin. The progressive vasodilatation due to the accumulation of prostaglandins was suppressed by indomethacin, the glomerular filtration rate remaining unchanged. The inhibition of prostaglandins synthesis was without influence on the natriuretic activity of furosemide. These results seem incompatible with an intrarenal mediation by prostaglandins of the diuretic effect of furosemide; moreover, this effect was dissociated from the changes in renal blood flow ascribed to renal prostaglandins.

References

Jan 1, 1977·Pflügers Archiv : European journal of physiology·G Kövér, H Tost
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·S Y Tan, P J Mulrow
Jul 1, 1976·European Journal of Pharmacology·E OliwE Anggård
Sep 1, 1976·Kidney International·R J AndersonR W Schrier
Oct 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H E WilliamsonD E Van Orden
Jun 26, 1975·Pflügers Archiv : European journal of physiology·J L VanherweghemA D'Hollander
Jun 1, 1973·Circulation Research·A J LonigroJ C McGiff
Mar 1, 1974·European Journal of Pharmacology·C Larsson, E Anggård
Jan 1, 1967·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·A NizetK Kramer
Jan 1, 1971·The American Journal of Physiology·B M Brenner, J H Galla

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Citations

Jan 10, 2014·Journal of Clinical Neonatology·Mitul Babubhai KalathiaIla Mitulkumar Kalathia

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