Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report

Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Giovana Memari PavanelliMarcelo Mazza do Nascimento

Abstract

Pseudoporphyria is a rare photodermatosis with characteristics similar to those of porphyria cutanea tarda, without, however, presenting abnormalities in porphyrin metabolism. Its etiology is related to chronic kidney disease, ultraviolet radiation and certain medications. The aim of the present study is to describe a case of furosemide-related pseudoporphyria in a patient with chronic kidney disease. A 76-year-old male patient with stage 4 chronic kidney disease and in continuous use of furosemide presented ulcerated lesions with peripheral erythema and central hematic crust in the legs. On a skin infection suspicion, treatment with quinolone and neomycin sulfate was initiated, without improvement. A biopsy of the lesion was performed, with histopathological examination demonstrating findings compatible with porphyria, although the patient did not present high porphyrin levels. The diagnosis of furosemide-induced pseudoporphyria was then established, with medication suspension, and there was a significant improvement of the lesions. There are few cases of pseudoporphyria described, but it is believed that this condition is underdiagnosed, especially in patients with chronic kidney disease. Both clinical and histopathological f...Continue Reading

References

Feb 1, 1992·Journal of Cutaneous Pathology·B Maynard, M S Peters
Jul 1, 1991·Journal of the American Academy of Dermatology·C Dabski, E H Beutner
Jul 1, 1987·Clinical and Experimental Dermatology·D A Burns
Mar 1, 1984·The Journal of Investigative Dermatology·J T KeaneF D Malkinson
Jan 10, 2001·Journal of the American Academy of Dermatology·J J Green, S M Manders
Nov 26, 2003·Journal of the American Academy of Dermatology·Jean-François Tremblay, Bertrand Veilleux
Jul 10, 2004·Journal of the American Academy of Dermatology·Kevan G LewisLeslie Robinson-Bostom
Oct 12, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Timur A GalperinKieron S Leslie
Sep 19, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Till WeidnerPeter Elsner

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