Furosemide induced release of prostaglandin E to increase renal blood flow.

Proceedings of the Society for Experimental Biology and Medicine
H E WilliamsonD E Van Orden

Abstract

Levels of PGE in renal venous blood were found to be significantly elevated at the time RBF was increased by furosemide. Following indomethacin, a second dose of furosemide failed to increase RBF and levels of PGE in renal venous blood were not elevated. Levels of PGF and PGA were not affected by furosemide. The increase of PGE in renal venous blood at the time of renal dilation supports the hypothesis that furosemide increases RBF by releasing PGE. An intrarenal action of the released PGE is implied by this mechanism.

Citations

Jan 3, 1977·European Journal of Clinical Pharmacology·K J Berg
May 1, 1988·Pflügers Archiv : European journal of physiology·J Greven, A Farjam
Jul 25, 1980·European Journal of Pharmacology·D C BraterW B Campbell
Dec 1, 1980·Prostaglandins·R Franco-SaenzS Y Tan
Jan 1, 1981·Pharmacology & Therapeutics·P C Weber, W Siess
May 18, 1999·Pharmacology & Toxicology·J S Petersen
Oct 1, 1979·Klinische Wochenschrift·P C WeberJ Schnermann
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·P C WeberB Scherer
Dec 1, 1980·Archives internationales de physiologie et de biochimie·A Nizet
Dec 1, 1977·Kidney International·K L DuchinT J Burke
Dec 1, 1991·Kidney International·B MemoliV E Andreucci
Sep 3, 2010·Zeitschrift für medizinische Physik·Johanna C NissenHenrik J Michaely
Jan 9, 2008·Biochemical Pharmacology·Punniyakoti T VeeraveeduYoshifusa Aizawa
Sep 1, 1979·Prostaglandins·A A Attallah
Oct 1, 1983·British Journal of Clinical Pharmacology·R DüsingH J Kramer
Nov 1, 1986·Journal of Clinical Pharmacology·D E Hutcheon, J C Martinez
Oct 1, 1990·Journal of Applied Toxicology : JAT·J R BucherE F Meierhenry
Dec 1, 1982·Circulation Research·S SpitalewitzJ G Porush
Jan 1, 1980·Acta Medica Scandinavica·P YlitaloT Metsä-Ketelä
Jan 1, 1977·Acta Pharmacologica Et Toxicologica·U B Olsen
Jul 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey Segar, Jennifer G Jetton
Jan 1, 1992·Auris, Nasus, Larynx·O Michel, R Matthias

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