Furosemide stress test and interstitial fibrosis in kidney biopsies in chronic kidney disease.

BMC Nephrology
Jesús RiveroMagdalena Madero

Abstract

Interstitial fibrosis (IF) on kidney biopsy is one of the most potent risk factors for kidney disease progression. The furosemide stress test (FST) is a validated tool that predicts the severity of acute kidney injury (especially at 2 h) in critically ill patients. Since furosemide is secreted through the kidney tubules, the response to FST represents the tubular secretory capacity. To our knowledge there is no data on the correlation between functional tubular capacity assessed by the FST with IF on kidney biopsies from patients with chronic kidney disease (CKD). The aim of this study was to determine the association between urine output (UO), Furosemide Excreted Mass (FEM) and IF on kidney biopsies after a FST. This study included 84 patients who underwent kidney biopsy for clinical indications and a FST. The percentage of fibrosis was determined by morphometry technique and reviewed by a nephropathologist. All patients underwent a FST prior to the biopsy. Urine volume and urinary sodium were measured in addition to urine concentrations of furosemide at different times (2, 4 and 6 h). We used an established equation to determine the FEM. Values were expressed as mean, standard deviation or percentage and Pearson Correlation. ...Continue Reading

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Citations

May 10, 2020·Critical Care : the Official Journal of the Critical Care Forum·Jia-Jin ChenGeorge Kuo
May 1, 2020·International Journal of Molecular Sciences·Armando CocaJuan Bustamante-Munguira
May 30, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joachim H Ix, Michael G Shlipak

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biopsies
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