Furosemide, when used in combination with positive end-expiratory pressure, facilitates the resorption of extravascular lung water in experimental hydrostatic pulmonary oedema

Acta Anaesthesiologica Scandinavica
C J WickertsG Hedenstierna


The study aimed to establish whether furosemide given intravenously improved resorption of hydrostatic pulmonary oedema in 14 dogs mechanically ventilated with positive end-expiratory pressure (PEEP). Hydrostatic pulmonary oedema was created by simultaneous inflation of a left atrial balloon and rapid intravenous infusion of isotonic saline. The hydrostatic process was terminated by deflating the balloon and reducing the infusion rate. A PEEP of 10 cmH2O (1.0 kPa) was applied in all animals; in seven, furosemide was administered (diuretic group), 1 mg/kg intravenously as a bolus followed by an infusion of 0.5 mg/kg per hour, while the remaining seven dogs served as a control group. All dogs were studied for a period of 4 h. The extravascular lung water measured with the double indicator dilution technique was 28.3 +/- 3.8 (diuretic group) and 28.2 +/- 6.8 ml/kg (control group) during maximum oedema. It was reduced to 16.4 +/- 2.2 (diuretic group) vs 19.8 +/- 3.7 ml/kg (control group) after 4 h of resorption, P less than 0.05. Postmortem gravimetric values of extravascular lung water were 9.1 +/- 3.4 (diuretic group) vs 12.6 +/- 5.0 g/kg (control group). In the diuretic group the urinary output increased threefold, and haemoglob...Continue Reading

Associated Clinical Trials


Dec 13, 2003·American Journal of Respiratory and Critical Care Medicine·Michael QuintelLuciano Gattinoni
Aug 18, 2010·Acta Anaesthesiologica Scandinavica·E V SuborovL J Bjertnaes
Jul 1, 1996·Investigative Radiology·D M IancuR P Michel


Nov 1, 1979·The Journal of Clinical Investigation·J AliL D Wood
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May 11, 1975·Journal of Applied Physiology·R H DemlingL H Edmunds
Jul 1, 1990·Acta Anaesthesiologica Scandinavica·H BlomqvistG Hedenstierna
Jul 1, 1987·Acta Anaesthesiologica Scandinavica·C FrostellR Pieper
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·C FrostellC J Wickerts
May 1, 1986·Respiration Physiology·H van der ZeeA B Malik
Nov 1, 1986·Journal of Applied Physiology·G A LaineR E Drake
Mar 1, 1985·The Journal of Surgical Research·B L EndersonG S Moss
Aug 12, 1967·Lancet·D G AshbaughB E Levine
Jun 1, 1967·The Journal of Clinical Investigation·O R LevineA P Fishman
Nov 1, 1969·Canadian Anaesthetists' Society Journal·R W McIntyreP R Ramachandran
May 31, 1969·British Medical Journal·M L BhatiaS B Roy
Apr 1, 1984·The American Journal of Medicine·C J SchusterR J Henning
Jun 1, 1982·Circulation Research·R E DrakeJ C Gabel
May 1, 1965·Circulation Research·M L PEARCEJ BEAZELL
May 5, 1896·The Journal of Physiology·E H Starling

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