Furter investigations on the interaction between alpha-adrenoceptor antagonists and the central hypotensive effect of clonidine in rats, rabbits and dogs

Clinical and Experimental Pharmacology & Physiology
D Tsoucaris-KupferH Schmitt

Abstract

1. The interactions between five alpha-adrenoceptor blocking agents and clonidine have been studied in rats, rabbits and dogs after intracisternal injections. 2. Dibozane, ethomoxane, azapetine, dibenamine and thymoxamine reduced blood pressure in rats and an antagonism of the hypotensive effects of clonidine was detected for the first four drugs. 3. In rabbits, azapetine, dibenamine, dibozane and ethomoxane were hypotensive while thymoxamine had no effect on blood pressure. Dibozane and dibenamine reduced the hypotensive effect of clonidine. 4. In dogs, azapetine, dibozane and ethomoxane reduced blood pressure, while dibenamine induced an increase in blood pressure and thymoxamine was without effect. Only dibenamine antagonized the blood pressure lowering effect of clonidine. A definite conclusion could not be drawn with azapetine due to its long duration of action of action in both rabbits and dogs. 5. These results suggest that the central receptors involved in the hypotensive effect of clonidine differ from many other central receptors and vary according to the animal species. In addition the alpha-adrenoceptor blocking agents appear not to have a unique site and mechanism of action on central cardiovascular control.

References

Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
May 1, 1977·British Journal of Pharmacology·J C DoxeyJ M Walker
Dec 1, 1977·British Journal of Pharmacology·J C Doxey, J Everitt
Oct 1, 1977·Physiological Reviews·T C Westfall
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Wagner, O E Brodde
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·A G RoachI Cavero
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·D N FranzR J Neumayr
May 1, 1977·European Journal of Pharmacology·R R Vollmer, J P Buckley
Jun 1, 1976·Circulation Research·G M HutchinsJ K Boitnott
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo, B Hamberger
Jun 1, 1973·European Journal of Pharmacology·B Delbarre, H Schmitt
Nov 1, 1974·Clinical and Experimental Pharmacology & Physiology·D BogaievskyH Schmitt
Sep 1, 1974·Life Sciences·H S BoudierJ van Rossum
Sep 1, 1971·European Journal of Pharmacology·W Kobinger, A Walland
Oct 1, 1973·European Journal of Pharmacology·J N SinhaH Schmitt
Sep 1, 1974·Neuropharmacology·H A Struyker BoudierJ M van Rossum
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Sep 1, 1971·British Journal of Pharmacology·L O Farnebo, B Hamberger
Sep 1, 1969·International Journal of Neuropharmacology·N TodaK Shimamoto
Jan 1, 1971·European Journal of Pharmacology·P Bolme, K Fuxe
Sep 1, 1968·European Journal of Pharmacology·J W Constantine, W K McShane

❮ Previous
Next ❯

Citations

Dec 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·P JohanssonM Henning
Aug 19, 1999·Brain Research Bulletin·C Farsang, J Kapocsi
May 1, 1994·Medicinal Research Reviews·J Szejtli
Mar 1, 1981·Journal of Autonomic Pharmacology·H E ConnorP E Hicks
Jul 18, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M E Flores-SotoC Beas-Zárate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.