Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase

Journal of Peptide Science : an Official Publication of the European Peptide Society
Risa TakayamaFayna Garcia-Martin

Abstract

Ester linkage (s) is a key chemical connector in organic chemistry, including natural products, peptides, and synthetic polymers. We herein describe a straightforward method for the efficient formation of ester linkage (s) on solid-phase. This method simply involves the use of amide coupling reagents under microwave irradiation. The robustness of this method relies on the use of classical solid-phase coupling reagents, heating by microwave irradiation, and a short time period, which results in high yields and the minimization of racemization.

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Citations

Dec 20, 2019·Organic Letters·Wing Ho So, Jiang Xia
Oct 2, 2021·Frontiers in Chemistry·Cheng-Han Wu, John Chu

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