PMID: 6981583Jan 1, 1982Paper

Further aspects of T cell function in systemic lupus erythematosus

Immunological Communications
M E DefreitasN E Bianco

Abstract

Generation of effector cells, the expression of cell mediated lympholysis (CML) and the reactivity of mononuclear cells in solid cultures, were explored in patients with Systemic Lupus Erythematosus (SLE). While proliferative responses to alloantigens were comparable to the controls, a significant decrease in CML capacity was found in SLE T lymphocytes; further, T cells stimulated with a T cell mitogen in solid cultures showed a diminished proliferative response to soluble factors. Functional cell interaction defects rather than intrinsic T cell abnormalities may be operating in SLE.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T SakaneI Green
Nov 1, 1979·Clinical Immunology and Immunopathology·R S KrakauerJ T Sundeen
Oct 1, 1978·The Journal of Clinical Investigation·A Sagawa, N I Abdou
Jan 1, 1980·International Archives of Allergy and Applied Immunology·E Kondracki

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