Further characteristics of beta2-microglobulin binding to oral streptococci.

Infection and Immunity
D EricsonG Kronvall

Abstract

A total of 85 strains of oral bacteria representing Streptococcus mutans, S. sanguis, S. Mitior, S. salivarious, S. milleri, S. infrequens, S. durans, S. lactis, S. faecalis, S. faecium, S. equinus, Streptococcus species group E, Actinomyces, and one group A Streptococcus were tested for binding of aggregated human beta 2-microglobulin. Positive affinity between bacteria and aggregated human beta 2-microglobulin was detected in 36% of the strains. No apparent correlation with bacterial species, serotype, or group was noted. No positive strains were detected among seven group I:A S. sanguis strains (P < 0.01). Binding constants for one S. mutans strain indicated heterogeneous binding structures on the bacterial surface. The number of binding sites for aggregates of human beta 2-microglobulin involving multipoint attachment varied from 70 to 1,700 per bacterial cell. With whole saliva as buffer, a general increase in affinity was seen. Variations in salt concentrations of the buffers revealed different salt-dependent species-associated uptake patterns. Oral bacteria tended to have an uptake maximum at a salt concentration similar to that seen in saliva. Binding structures for aggregated beta 2-microglobulin on oral streptococci w...Continue Reading

References

Jan 1, 1977·Archives of Oral Biology·J Olsson, P O Glantz
Jan 1, 1976·Caries Research·I MagnussonK Pruitt
Jan 1, 1975·Annual Review of Microbiology·R J Gibbons, J V Houte
Mar 1, 1972·Journal of Dental Research·R J GibbonsW F Liljemark
Dec 1, 1966·Journal of Bacteriology·J M Jablon, D D Zinner

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