PMID: 479476Oct 1, 1979

Further characterization and biologic activity of ragweed antigen--induced neutrophil chemotactic activity in man

The Journal of Allergy and Clinical Immunology
P C AtkinsF Rosenblum

Abstract

We have previously described the appearance in serum of increased neutrophil chemotactic activity (NCA) during bronchospasm induced by inhalation of ragweed antigen in ragweed-sensitive subjects. This NCA is non-complement derived, appears within 1 min after antigen inhalation, and is not seen after methacholine-induced bronchospasm. This article describes further characterization of this chemotactic activity and correlation with in vivo leukocytosis. NCA consistently eluted in the void volume (fraction I) after Sephadex G-150 chromatography of patient serum obtained 10 min postchallenge. Fraction I contained 94% of the NCA of postchallenge whole serum. Both postchallenge whole serum and fraction I deactivated neutrophils to autologous chemoattractants and complement-derived chemotactic factors, but not serum-independent chemotactic factors. NCA was chemotactic for neither human nor guinea pig eosinophils, nor for human mononuclear cells. A significant increase of circulating neutrophils was seen only after antigen-induced bronchospasm and correlated with the increase in NCA. Thus, NCA represents another inflammatory mediator of probable mast cell origin that may explain, at least partially, the accumulation of neutrophils obse...Continue Reading

References

May 5, 1978·Science·M A IsturizA L Notkins
Feb 1, 1977·The Journal of Allergy and Clinical Immunology·E H DunskyB Zweiman
Jan 1, 1978·International Archives of Allergy and Applied Immunology·M NormanU R Nilsson
Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Dec 1, 1975·The Journal of Pediatrics·M NormanU R Nilsson
Mar 1, 1971·The Journal of Experimental Medicine·A B KayK F Austen
May 1, 1973·The Journal of Allergy and Clinical Immunology·P C AtkinsB Zweiman

Citations

May 1, 1989·Digestive Diseases and Sciences·R A KozolS A Elgebaly
Mar 4, 1982·The New England Journal of Medicine·L NagyA B Kay
Sep 1, 1980·The Journal of Allergy and Clinical Immunology·G L MartinB Zweiman
Nov 1, 1982·The Journal of Allergy and Clinical Immunology·E SchenkelB Zweiman
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·S I Wasserman, D M Center
Jan 1, 1984·Experimental Lung Research·J R Snapper, K L Brigham
Sep 1, 1983·International Journal of Dermatology·R F Lemanske, M A Kaliner
Jan 1, 1988·Pediatric Pulmonology·W M Abraham, A Wanner
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·I IwamotoS Yoshida

Related Concepts

Bronchial Provocation Tests
Chemotaxis, Leukocyte
Chromatography
Eosinophil
Differential White Blood Cell Count Procedure
Pleocytosis
Neutrophil Band Cells
Male Gametophytes

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