PMID: 9540070Apr 16, 1998Paper

Further characterization of human RNase MRP/RNase P and related autoantibodies

Molecular Biology Reports
R M Karwan

Abstract

We characterized a panel of human RNase MRP/RNase P autoantibodies by immunoprecipitation, immunodepletion, immunoaffinity purification and immunoblotting. We report on the protein spectrum that is recognized by RNase MRP/RNase P autoantibodies. We also describe another, related patient serum that based on these assays does not immunoprecipitate RNase P/MRP/Th40. This autoantibody 'KC', however, coimmunoprecipitates the RNase MRP/RNase P associated RNAs from HeLa and La9 cell extracts as shown by nuclease protection experiments.

Citations

Dec 17, 2002·Arthritis and Rheumatism·Hans Van EenennaamGer J M Pruijn
Jul 1, 2010·Wiley Interdisciplinary Reviews. RNA·Sandy MattijssenGer J M Pruijn

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