PMID: 6160839Feb 1, 1980Paper

Further characterization of natural killer cells induced by Kunjin virus

The Australian Journal of Experimental Biology and Medical Science
R I Macfarlan, D O White

Abstract

The natural killer (NK) cell induced one to two days after Kunjin virus infection of BALB/c mice is cytotoxic for a wide range of syngeneic, allogeneic and xenogeneic cell lines. It is also weakly cytotoxic for some non-malignant cells including mouse fibroblasts, macrophages and thymocytes, but not lymph node cells. Levels of lysis of non-tumour target cells are dependent on their genotype. Furthermore, malignant cell lines may become resistant following transplantation in vivo then susceptible again after culture in vitro. The virus-induced NK cell is elicited as readily in athymic (nude) as in normal mice. X-irradiation inhibits its development if administered prior to infection. It is labile on culture at 37 degrees. The cell carries Fc receptors but its NK activity is not antibody-dependent.

Citations

Nov 15, 2006·Immunological Reviews·Christopher E AndoniouMariapia A Degli-Esposti
Jan 1, 1974·Journal of Neurobiology·P E Pickens

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