Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia

Skin Appendage Disorders
Ralph M Trüeb

Abstract

Observations on the Laron syndrome originally offered the opportunity to explore the effect of insulin-like growth factor 1 (IGF-1) deficiency on human hair growth and differentiation. According to its expression in the dermal hair papilla, IGF-1 is likely involved in reciprocal signaling. It has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology. Of all the cytokines or growth factors that have been postulated to play a role in hair follicles, ultimately IGF-1 is known to be regulated by androgens. Accordingly, dermal papillary cells from balding scalp follicles were found to secrete significantly less IGF-1 than their counterparts from nonbalding scalp follicles. Herein, hypotrichosis in primary growth hormone deficiency, and a lack of response of female and male androgenetic-type alopecia to treatment with topical minoxidil and oral finasteride in patients who had undergone surgical resection of the pituitary gland, provide further evidence for an effect of IGF-1 on hair growth and alopecia.

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Citations

Aug 10, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Young In LeeJu Hee Lee
Feb 18, 2021·Signal Transduction and Targeted Therapy·Shuaifei JiXiaobing Fu
Apr 2, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Hyeon Ju ParkBog-Hieu Lee
Jul 24, 2021·Journal of Ginseng Research·Van-Long TruongWoo-Sik Jeong
Apr 8, 2020·Skin Appendage Disorders·Murilo Calvo PerettiRalph M Trüeb

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