PMID: 1212659Dec 11, 1975Paper

Further clinical studies with intrahepatic arterial infusion with 5-fluorouracil

Cancer
F J AnsfieldM Esmili

Abstract

A total of 419 patients with progressive liver disease, in nearly all cases metastatic from gastrointestinal primaries, were treated by intrahepatic arterial infusion with 5-FU. Three-fourths of these patients had had prior trials with intravenous 5-FU for 1 or 2 months to several years and had been switched to the infusion upon the development of progression. Catheters were placed percutaneously and the patients infused with 5-FU at a dose of 20 to 30 mg/kg/day X 4, then 15 mg/kg/day X 17, at which point the catheter was removed and the patient sent home on weekly i.v. doses at 15 mg/kg. Toxicity, morbidity, and mortality were minimal with the intrahepatic arterial infusion treatment and the rigid criteria of improvement were met by 55% of the study cases. The survival rate of those patients who responded to the treatment was greater than the survival rate of those who failed to respond.

References

Feb 1, 1971·American Journal of Surgery·W H MasseyD L Dennis
Nov 1, 1971·Cancer·F J AnsfieldG W Wirtanen
Jul 28, 1962·JAMA : the Journal of the American Medical Association·F J ANSFIELDA R CURRERI
Nov 16, 1964·JAMA : the Journal of the American Medical Association·F J ANSFIELD

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Citations

Feb 1, 1978·The British Journal of Surgery·I Taylor
May 1, 1980·Diseases of the Colon and Rectum·A M CohenP J Blackshear
Jan 1, 1980·Journal of Surgical Oncology·C P KarakousisE D Holyoke
Jun 15, 1993·Cancer·D J Vaughn, D G Haller
Aug 1, 1987·World Journal of Surgery·C M Balch, B Levin
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·B Glimelius, L Påhlman
Dec 1, 1987·Journal of Surgical Oncology·P J O'Dwyer, J P Minton
May 1, 1983·Diseases of the Colon and Rectum·A Y Bedikian
Jan 1, 1983·Cancer Investigation·Y T Lee
Feb 1, 1993·Australian and New Zealand Journal of Medicine·F M BoyleJ A Levi
Jul 1, 1996·Seminars in Surgical Oncology·Y FongA M Cohen
Jun 1, 1985·Diseases of the Colon and Rectum·A M CohenW C Wood
Jan 1, 1989·Journal of the Royal Society of Medicine·T G Allen-Mersh
Aug 1, 1980·The Australian and New Zealand Journal of Surgery·F O StephensD M Lonergan
Jan 1, 1987·Journal of Surgical Oncology·J L Burkhalter, J U Morano
Jan 1, 1985·Cancer Drug Delivery·H J Keizer, H M Pinedo
Jan 1, 1980·Acta Radiologica. Oncology·W MattssonL Hallsten
Dec 1, 1980·The Australian and New Zealand Journal of Surgery·B N Gray
Feb 22, 2007·AJR. American Journal of Roentgenology·Sakae NagaokaMichio Sata
Jan 1, 1980·Journal of Surgical Oncology·L HafströmK Sundqvist
May 1, 1980·Acta Pharmacologica Et Toxicologica·O E AlmersjöP Wåhlén
Oct 1, 1984·Journal of Surgical Oncology·A S Al-JurfL F Urdaneta
Jan 1, 1981·The Japanese Journal of Surgery·S FujimotoK Okui
Jul 1, 1985·The British Journal of Surgery·I Taylor
Nov 1, 1990·Journal of Gastroenterology and Hepatology·K TakayasuY Moriya

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