Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors

European Journal of Pharmacology
G CathelineG Guilbaud

Abstract

The contribution of a peripheral action of morphine in the augmented antinociceptive effect of this substance was re-evaluated in a well established rat model of peripheral unilateral mononeuropathy (chronic constriction of the common sciatic nerve), using a relatively low dose of systemic morphine (1 mg/kg i.v.) and local low doses of specific antagonists of kappa- (nor-binaltorphimine) or delta-(naltrindole) opioid receptors. Vocalization thresholds to paw pressure were used as a nociceptive test. Escalating doses of nor-binaltorphimine (10-30 micrograms injected locally into the nerve injured paw) significantly and dose dependently reduced the effect of morphine on this paw but not on the contralateral paw, an effect which plateaued at 30 micrograms. By contrast, the local injection of naltrindole (30-40 micrograms into the nerve injured paw) had no effect on morphine analgesia. The doses of opioid receptor antagonists used, injected i.v., in the contralateral paw, or alone in the nerve injured paw had no significant effect. These results suggest that the peripheral effect of systemic morphine in this model of neuropathic pain could be mediated not only by mu- but also by kappa-opioid receptors.

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Citations

Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Linda S Sorkin, Tony L Yaksh
Nov 8, 2001·European Journal of Pharmacology·A Pertovaara, H Wei
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jun 24, 2004·European Journal of Pharmacology·Indre Bileviciute-Ljungar, Mariana Spetea
Jul 2, 2005·Expert Opinion on Investigational Drugs·A Barber, R Gottschlich
Apr 15, 2004·Neuroscience Letters·Ilona ObaraBarbara Przewlocka

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