PMID: 9178856May 9, 1997Paper

Further evidence for an association between a mutation in the APP gene and Lewy body formation

Neuroscience Letters
G HallidayG A Broe

Abstract

There have been two detailed neuropathological reports of families with a valine to isoleucine substitution at position 717 of the amyloid precursor protein gene. Surprisingly, in one of these families substantial Lewy body formation occurred in addition to Alzheimer's disease, prompting the speculation that such a genetic mutation may predispose to both Lewy body and plaque formation. This report describes the neuropathology of an additional family with the same genetic mutation. Of two affected members who have come to autopsy, one had brainstem Lewy bodies. Some of these Lewy bodies had peripheral halos immunoreactive for beta-amyloid. These findings suggest a greater than chance link between genetic mutations for Alzheimer's disease and Lewy body formation.

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Citations

May 24, 2012·Acta Neuropathologica·Gerard D Schellenberg, Thomas J Montine
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·E MasliahL Mucke
Dec 17, 2008·Revue neurologique·L Guyant-MaréchalD Hannequin
Jun 18, 2016·Neurobiology of Disease·Joshua T GeigerSonja W Scholz
Apr 18, 1998·Brain Pathology·P G InceC M Morris
Jul 11, 2000·Journal of Neuropathology and Experimental Neurology·E B Mukaetova-LadinskaC M Wischik
Jan 27, 2021·Annual Review of Pathology·Caitlin S LatimerThomas J Montine
Dec 9, 2020·Journal of Alzheimer's Disease : JAD·Thomas G Beach, Michael Malek-Ahmadi

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