Further evidence for differences between cardiac atypical beta-adrenoceptors and brown adipose tissue beta3-adrenoceptors in the pithed rat

British Journal of Pharmacology
Barbara Malinowska, Eberhard Schlicker

Abstract

1. We have previously shown (Malinowska & Schlicker, 1996) that the atypical beta-adrenoceptor involved in the positive chronotropic effect of the so-called non-conventional partial beta-adrenoceptor agonists CGP 12177 and cyanopindolol in the pithed rat possesses properties markedly different from those observed for beta3-adrenoceptors in the literature. In the present study, we have directly compared the pharmacological properties of the atypical cardiostimulant beta-adrenoceptor and of the beta3-adrenoceptor mediating the thermogenic response in the brown adipose tissue in pithed and vagotomized rats. 2. Heart rate was dose-dependently increased by CGP 12177 and cyanopindolol by maximally 150 and 100 beats min(-1), yielding pED50 values of 8.0 and 7.3, respectively (pED50, -log10 of the dose in mol kg(-1) body weight i.v. causing the half-maximum effect), but not affected by the selective beta3-adrenoceptor agonist CL 316243 (pED50 > 6.0). 3. CGP 12177, cyanopindolol and CL 316243 increased temperature in the brown adipose tissue by maximally 1 degree C (pED50 values 7.4, 6.3 and 8.6, respectively). 4. The beta1-adrenoceptor antagonist CGP 20712 10 micromol kg(-1), attenuated the cardiostimulatory effect of CGP 12177 and, at...Continue Reading

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Citations

Feb 28, 2002·European Journal of Pharmacology·Lee K ChongPeter T Peachell
Aug 10, 1999·European Journal of Pharmacology·T Horinouchi, K Koike
Feb 19, 2002·Current Opinion in Biotechnology·R N Patel
Feb 22, 2000·British Journal of Pharmacology·L BrawleyA MacDonald
May 3, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Eberhard SchlickerBarbara Malinowska
May 27, 2008·Pharmacology & Therapeutics·Alberto J Kaumann, Peter Molenaar
Sep 10, 2005·British Journal of Pharmacology·Agnieszka ZakrzeskaBarbara Malinowska
Apr 7, 2005·Fundamental & Clinical Pharmacology·Dorota ZelaszczykEberhard Schlicker
Aug 23, 2005·European Journal of Pharmacology·Tadanori SugimotoYuichi Yokoyama
Feb 26, 2019·British Journal of Pharmacology·Ebru Arioglu-InanMartin C Michel
Mar 12, 2002·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·T HorinouchiK Koike
Jun 8, 1999·The Journal of Biological Chemistry·D K RohrerB K Kobilka
Jun 19, 2002·Cardiovascular Drug Reviews·Stéphane Moniotte, Jean-Luc Balligand
Feb 13, 2001·American Journal of Physiology. Endocrinology and Metabolism·J G Granneman

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