Further evidence for genetic association of CACNA1C and schizophrenia: new risk loci in a Han Chinese population and a meta-analysis

Schizophrenia Research
Fanfan ZhengWeihua Yue

Abstract

CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizophrenia, we conducted a case-control study in 5897 schizophrenic patients and 6323 healthy control subjects selected from Han Chinese population. Our study replicated the positive associations of rs1006737 (P=0.0108, OR=1.16, 95% CI: 1.03-1.29) and rs1024582 (P=0.0062, OR=1.18, 95% CI: 1.05-1.33), and identified a novel risk locus, rs2007044 (P=0.0053, OR=1.08, 95% CI: 1.02-1.14). A meta-analysis of rs1006737 combining our study and previous studies was conducted in a total of 8222 schizophrenia cases and 24,661 healthy controls. In the meta-analysis, the association between rs1006737 and schizophrenia remained significant (OR=1.14, 95% CI: 1.07-1.22, P=0.0001). Stratified analysis showed no heterogeneity between East Asian and European ancestries (χ(2)[1]=0.07, P=0.795), and the difference in pooled ORs between ancestries was not significant (Z=0.25, P=0.801). Our results provide further support for associations of ...Continue Reading

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Citations

Jan 13, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Liang HuangMing Li
Aug 1, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fayi NieJie Ma
Jan 16, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Hongyan JiangLi Yu
Oct 28, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jianjun OuXiao Xiao
Jun 14, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Donna CosgroveGary Donohoe
Jul 10, 2018·Schizophrenia Bulletin·Anna L MoonJeremy Hall
Dec 17, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fanglin GuanTianxiao Zhang
Jul 25, 2019·International Journal of Molecular Sciences·Arturo AndradeLaura Londrigan
May 4, 2021·The Australian and New Zealand Journal of Psychiatry·Zuxing WangXingguang Luo

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