Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: a combined twin and family study

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Mei-Hua HallF Rijsdijk

Abstract

P50 suppression deficit has been reported in patients with psychotic bipolar disorder. In our previous report on twin pairs concordant and discordant for bipolar disorder, we found significant genetic overlap between bipolar disorder and P50 sensory gating. However, the sample size in that study was relatively small. A separate study, the Maudsley Bipolar Family Study, reported diminished P50 gating in unaffected relatives of psychotic bipolar patients. However, genetic and environmental influences are confounded in family studies due to lack of monozygotic (MZ) twin pairs. The current study combines the twin sample and the family sample in order to improve statistical power and study design, with the aims of: (1) substantiating the association between psychotic bipolar disorder and diminished P50 suppression and (2) verifying the genetic overlap between the two traits reported in the twin sample. We also assessed the relationship between bipolar disorder and an alternative suppression index, the P50 Condition-Testing (C-T) amplitude difference. A total of 309 subjects was included in this study, comprising 91 twin pairs, 31 bipolar families, and 45 unrelated healthy controls. Statistical analyses were based on structural equat...Continue Reading

References

Oct 1, 1992·Journal of Psychiatric Research·S Matthysse, J Parnas
Nov 10, 1988·Nature·E S Lander
Sep 1, 1994·Psychophysiology·D A SmithS B Schwarzkopf
Dec 1, 1993·The American Journal of Psychiatry·L E AdlerR Freedman
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R FreedmanW Byerley
Dec 8, 1998·The American Journal of Psychiatry·B A ClementzD L Braff
Mar 24, 1999·Biological Psychiatry·R FreedmanS Leonard
Feb 24, 2001·Behavior Genetics·D PosthumaD Boomsma
Jul 27, 2001·American Journal of Medical Genetics·R J Gorlin
Sep 6, 2001·Experimental Brain Research·B A Clementz, L D Blumenfeld
May 7, 2002·American Journal of Medical Genetics·Robert H LenoxHusseini K Manji
Nov 5, 2002·Nature Reviews. Genetics·Dorret BoomsmaLeena Peltonen
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
May 14, 2003·Archives of General Psychiatry·Peter McGuffinAlastair Cardno
Jun 13, 2003·American Journal of Human Genetics·Ricardo SeguradoNurten Akarsu
Mar 25, 2004·Biological Psychiatry·Marina Myles-WorsleyRobert Freedman
Apr 2, 2004·The American Journal of Psychiatry·J Raymond DePaulo
Aug 27, 2004·Schizophrenia Research·Elvira BramonSophia Frangou
Feb 15, 2005·Neurochemistry International·Barkur S Shastry
Mar 3, 2005·The American Journal of Psychiatry·Sandrine Louchart-de la ChapelleFlorence Thibaut
May 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Nick Craddock, Michael J Owen
Sep 17, 2005·Psychological Medicine·F V RijsdijkP C Sham
Jan 13, 2006·Biological Psychiatry·Gregor HaslerHusseini K Manji
Mar 4, 2006·The American Journal of Psychiatry·Colm McDonaldRobin M Murray
Jul 11, 2006·Behavior Genetics·Mei Hua HallPak Sham
Sep 2, 2006·The American Journal of Psychiatry·Gerome BreenDavid Collier
Jan 17, 2007·Psychological Medicine·Mei-Hua HallRobin M Murray
May 4, 2007·The American Journal of Psychiatry·Mei-Hua HallPak Sham

❮ Previous
Next ❯

Citations

Oct 3, 2009·Psychological Medicine·W T CarpenterM J Green
Jan 28, 2010·Psychological Medicine·M ShaikhE Bramon
May 27, 2008·Schizophrenia Bulletin·Gunvant K Thaker
Jan 6, 2010·Harvard Review of Psychiatry·Mei-Hua Hall, Jordan W Smoller
May 21, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Inés AncínAna Barabash
May 4, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·M De PradierC Dubertret
Dec 4, 2009·Neuroscience and Biobehavioral Reviews·Elena I IvlevaCarol A Tamminga
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Peter DomeZoltan Rihmer
Aug 20, 2009·Bipolar Disorders·Julie V PattersonWilliam E Bunney
Mar 28, 2013·Bipolar Disorders·Julie V PattersonWilliam E Bunney
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H W ThermenosL J Seidman
Mar 6, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mei-Hua HallJordan W Smoller
Jan 4, 2015·Schizophrenia Research·Madiha ShaikhElvira Bramon
Sep 29, 2012·Psychiatry Research·Dominique H HolsteinDominique Eich
Sep 12, 2013·Journal of Affective Disorders·Ying WangLi Huang
Jul 10, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·José A CabranesAna Barabash
Mar 13, 2016·Psychiatry and Clinical Neurosciences·Massimiliano BuoliA Carlo Altamura
Jun 14, 2016·Journal of Affective Disorders·Chia-Hsiung ChengShih-Chieh Hsu
Aug 1, 2013·Expert Review of Neurotherapeutics·Mariane Nunes NotoElisa Brietzke
Feb 6, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Judith M GaultAviva Abosch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.