Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients.

European Journal of Clinical Pharmacology
Arzu GunesMaria Gabriella Scordo

Abstract

Antipsychotic-induced extrapyramidal side effects (EPS) are still a major problem in the treatment of schizophrenia. Serotonin 2C receptors (5-HT(2C)) have regulatory effects on dopaminergic pathways in brain regions involved with EPS. Polymorphisms in the 5-HT(2C) gene (HTR2C) have been suggested to be associated with the risk of developing EPS. Our purpose was to evaluate the impact of polymorphisms in the HTR2C gene on the occurrence of EPS in male schizophrenic patients. Ninety-nine male Caucasian chronic schizophrenic patients on long-term treatment with classical antipsychotics were genotyped for the -997 G/A, -759 C/T, -697 G/C and Cys23Ser polymorphisms of HTR2C. EPS (dystonia, parkinsonism, tardive dyskinesia) were assessed by the Simpson-Angus Scale and the Abnormal Involuntary Movement Scale. Fifty-one patients had current or previous history of EPS, whereas 48 patients had no symptoms or history of EPS. To rule out a possible association between HTR2C polymorphisms and schizophrenia, 112 healthy male volunteers were also genotyped. Allele frequencies of -997A, -759T and -697C did not differ between the groups, whereas patients with EPS had a significantly (p = 0.025) higher frequency of the 23Ser allele (0.29) than ...Continue Reading

References

Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Jan 1, 1980·Annual Review of Neuroscience·R J Baldessarini, D Tarsy
May 1, 1996·Neuroscience·K Eberle-WangM F Chesselet
Jul 28, 1997·The Journal of Comparative Neurology·K Eberle-WangM F Chesselet
Apr 3, 1999·British Journal of Pharmacology·C ReavillT P Blackburn
Feb 24, 2001·European Journal of Clinical Pharmacology·M G ScordoF Sjöqvist
Jun 14, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernard LererFabio Macciardi
May 4, 2004·The American Journal of Psychiatry·Anil K MalhotraJames L Kennedy
Aug 12, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Salim Mottagui-TabarMarkus Heilig
Jan 26, 2005·Synapse·Katherine D AlexElizabeth A Pehek
Mar 3, 2005·The American Journal of Psychiatry·Paul R BucklandMichael C O'Donovan
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanUNKNOWN Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators

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Citations

Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Dennis H KimStephen M Stahl
Feb 25, 2009·The Pharmacogenomics Journal·C C ZaiJ L Kennedy
Jun 10, 2009·The Pharmacogenomics Journal·P GassóA Lafuente
Aug 30, 2008·Schizophrenia Bulletin·Maria J Arranz, Shitij Kapur
Jul 14, 2011·Psychopharmacology·Jeroen P KoningUNKNOWN Genetic Risk and Outcome in Psychosis (GROUP) investigators
Sep 14, 2010·Clinics in Laboratory Medicine·Peter P Zandi, Jennifer T Judy
Dec 1, 2015·Pharmacology & Therapeutics·Giuseppe Di Giovanni, Philippe De Deurwaerdère
Feb 18, 2010·The Psychiatric Clinics of North America·Peter P Zandi, Jennifer T Judy
Aug 7, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·James T TeoKailash Bhatia
Mar 26, 2016·Progress in Neurobiology·Philippe De Deurwaerdère, Giuseppe Di Giovanni
Jun 23, 2011·Neuroscience and Biobehavioral Reviews·Judith R Homberg
May 31, 2012·European Journal of Pharmacology·Nabila KadiriSylvia Navailles
Apr 14, 2012·European Journal of Pharmacology·Jan Anker Jahnsen, Staffan Uhlén
Jun 19, 2018·Journal of Clinical Psychopharmacology·Svetlana A IvanovaAnton J M Loonen
Sep 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Antonio Drago, Alessandro Serretti
Jul 3, 2009·Social Studies of Science·Barbara Prainsack, Martin Kitzberger
Feb 21, 2009·Journal of Cellular and Molecular Medicine·Irmgard Tegeder, Jörn Lötsch
Apr 24, 2013·Journal of Clinical Psychopharmacology·Wilma KnolToine C G Egberts
Sep 13, 2018·The Mental Health Clinician·Tonya Gross, Jeremy Daniel

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