PMID: 7149988Sep 1, 1982

Further evidence for the participation of 5 beta-steroids in the development of a porphyria induced by hexachlorobenzene

Archives of Toxicology
V GraefC Tyrell

Abstract

Adult female rats were fed with a diet containing hexachlorobenzene to induce a porphyria. 5 alpha/5 beta-ratios of androstane steroids in blood were 0.61 +/- 0.13 in porphyric rats and 1.05 +/- 0.35 in normal rats. Etiocholanolone treatment of rats was ineffective in generation of a porphyria. The activity of microsomal glucuronyltransferase increased from 0.20 +/- 0.04 mU/mg to 0.77 +/- 0.23 mU/mg by this treatment. Administration of Flutamide (4'-nitro-3'-trifluoromethylisobutyranilide) to porphyric rats resulted in a decline of porphyrin excretion by 55%. The hepatic NADH-5 beta-reductase was strongly inhibited by this drug, whereas NADPH-5 beta-reductase displayed a slightly increased activity. These findings are further evidence for the involvement of 5 beta-steroids in the formation of porphyria.

Citations

Jan 1, 1976·Hoppe-Seyler's Zeitschrift für physiologische Chemie·S W GolfE Nowotny
Oct 1, 1978·The Journal of Clinical Endocrinology and Metabolism·D K FukushimaB Zumoff
Dec 1, 1977·The Journal of Clinical Endocrinology and Metabolism·L HellmanB Zumoff
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·A KappasS Granick

Related Concepts

Molecular Stereochemistry
Disorders of Porphyrin Metabolism
Glucuronosyltransferase
androstane-3,17-dione, (4-(3)H-labeled, (4beta,5beta))-isomer
Oxidase
Hepatic
AKR1D1 protein, human
Etiocholanalone Measurement
NADH
Catatoxic Steroids

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