Further evidence for zinc as a hepatoprotective agent in rat liver toxicity

Experimental and Molecular Pathology
D Dhawan, A Goel

Abstract

The present study was envisaged to investigate the protective effects of zinc treatment on the activities of various drug metabolizing enzymes, reduced glutathione content, and extent of lipid peroxidation in the livers of male albino rats subjected to long-term carbontetrachloride (CCl4) toxicity. It was observed that the activities of cytochrome P450, cytochrome b5, NADPH-cytochrome-c-reductase, and glutathione concentrations were significantly depressed following treatment with CCl4 for 6 weeks. At the same time, a marked elevation was seen in the extent of NADPH-dependent lipid peroxidation after CCl4 toxicity. Moreover, significantly depressed concentrations of zinc (Zn2+) were observed in both serum and liver after 6 weeks of the CCl4 administration. However, simultaneous zinc treatment to CCl4-intoxicated rats resulted in significant improvement in the activities of most of the drug metabolizing enzymes as well as the glutathione levels. Similarly, zinc treatment also normalized the CCl4-induced increase in the extent of NADPH-dependent lipid peroxidation. We conclude that zinc supplementation considerably attenuates the liver injury induced by chronic CCl4 treatment to rats.

Citations

Jun 12, 2002·The American Journal of Pathology·Zhanxiang ZhouY James Kang
Dec 29, 2007·Drug and Chemical Toxicology·Ashima PathakD Dhawan
Dec 17, 2008·Nutrition Research·Anshoo Malhotra, Devinder K Dhawan
May 17, 2002·Journal of Applied Toxicology : JAT·A PathakD Dhawan
Jun 27, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Pardeep SidhuD K Dhawan
Aug 29, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ajay GoelD K Dhawan
Apr 27, 2007·Cellular and Molecular Neurobiology·Punita BhallaD K Dhawan
May 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Pardeep SidhuD K Dhawan
Apr 7, 2007·Digestive Diseases and Sciences·Ioannis StamoulisStamatios Theocharis
May 20, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·W M CaseyN F Cariello
Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K Zierold
Nov 13, 2003·Experimental and Molecular Pathology·William E Stehbens
Nov 13, 2004·Chemico-biological Interactions·Pardeep SidhuD K Dhawan

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