Further evidence of cholinergic impairment of the neuroendocrine control of the GH secretion in Down's syndrome

Dementia and Geriatric Cognitive Disorders
L BeccariaG Chiumello

Abstract

There are data indicating that cholinergic activity is precociously impaired in Down's syndrome (DS). On the other hand, acetylcholine as well as arginine (ARG) play a major stimulatory role in the neural control of growth hormone (GH) secretion in humans, likely acting via the inhibition of hypothalamic somatostatin release. The aim of the present study was to verify the effects of pyridostigmine (PD, 120 mg p.o.), a cholinesterase inhibitor, and ARG (0.5 g/kg i.v.) on the growth hormone-releasing hormone (GHRH) (1 microgram/kg i.v.)-induced GH rise in 15 adult patients with DS (M/F: 8/7; age 26.5 +/- 2.2 years; body mass index, BMI: 25.7 +/- 1.0 kg/m2) in which the potentiating effect of PD on GH secretion has been reported to be reduced. The results in DS were compared to those in 15 normal subjects (NS) (M/F: 8/7; age: 30.0 +/- 1.3 years; BMI: 21.4 +/- 0.4 kg/m2). Basal GH and insulin growth factor I (IGF-1) levels in DS (1.8 +/- 0.7 and 206.5 +/- 21.0 micrograms/l) were similar to those in NS (1.4 +/- 0.3 and 179.4 +/- 11.0 micrograms/l). The GH response to GHRH alone in DS (526.5 +/- 120.1 micrograms/l/h) was lower (p < 0.05) than that recorded in NS (895.4 +/- 153.7 micrograms/l/h). The GHRH-induced GH rise was potentiat...Continue Reading

Citations

Jul 27, 2001·Journal of Chromatography. a·T VerleyenW De Greyt
Nov 19, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P KovesdyKamyar Kalantar-Zadeh
Aug 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Csaba P Kovesdy
Jan 26, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kalani L RaphaelSrinivasan Beddhu
Aug 8, 2015·Clinical Kidney Journal·Carlo Basile, Carlo Lomonte
Sep 9, 2017·American Journal of Medical Genetics. Part a·Sarah J HartGail A Spiridigliozzi
Dec 21, 2018·American Journal of Medical Genetics. Part a·Clotilde MircherAimé Ravel
Jul 18, 2009·Journal of the American Society of Nephrology : JASN·Ione de Brito-AshurstMuhammad M Yaqoob
Feb 28, 2004·Molecular Endocrinology·Eleni GoshuChen-Ming Fan
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Dennis Y WuKamyar Kalantar-Zadeh
Nov 9, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Robert YenchekUNKNOWN Health, Aging, and Body Composition Study
Jul 17, 2009·American Journal of Medical Genetics. Part a·Priya S KishnaniThomas McRae
Apr 27, 2000·Proceedings of the Society for Experimental Biology and Medicine·B R LackeyD M Henricks
Apr 12, 2016·American Journal of Medical Genetics. Part a·Gail A SpiridigliozziPriya S Kishnani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Archiv für Psychiatrie und Nervenkrankheiten
A Pentschew
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Matthew K AbramowitzMichal L Melamed
The American Journal of Clinical Nutrition
Danika KruppThomas Remer
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Vandana MenonMark J Sarnak
© 2022 Meta ULC. All rights reserved