Further evidence of the association of latent Mycobacterium tuberculosis in Eales' disease.

International Ophthalmology
Prasad Gupta, Jyotirmay Biswas

Abstract

To find out association of Eales' disease with Mycobacterium tuberculosis. A retrospective study was done recruiting patients visiting the uvea clinic with diagnosis of Eales' disease from 2015-2019. Seventy-nine eyes of 50 patients diagnosed as Eales' disease underwent Mantoux test, QuantiFERON-TB Gold test, high resolution computed tomography (HRCT) of the chest and anterior chamber or vitreous tap for TB genome polymerase chain reaction(PCR). The study included 41 males and 9 females. The mean age of the patient was 35.62 ± 11.49 y. Out of 50 patients, 42% (n = 21) patients had unilateral involvement. Mantoux test was positive in 73% patients. QuantiFERON-TB Gold test was positive in 56% patients. HRCT chest was suggestive of pulmonary tuberculosis in 34% patients. Out of 6 patients, PCR from anterior chamber tap showed TB genome positive in 2 (33.3%) patients. Out of 9 patients, vitreous tap PCR was positive for TB genome in 2 (22.2%) patients. Our study showed that one or more tests were positive for TB in Eales' disease suggesting a pivotal role of TB as a primary etiology for this disease. We conclude that Eales' disease is associated with Mycobacterium tuberculosis infection.

References

Jun 8, 2002·Survey of Ophthalmology·Jyotirmay BiswasS Ramakrishnan
Apr 11, 2012·Ocular Immunology and Inflammation·Rishiraj SinghAmod Gupta
Mar 22, 2013·Journal of Ophthalmic Inflammation and Infection·Jyotirmay BiswasHajib Naraharirao Madhavan
Jan 20, 2017·Journal of Ophthalmic Inflammation and Infection·Ranju Kharel SitaulaJyotirmay Biswas
Apr 28, 2017·Ocular Immunology and Inflammation·Jyotirmay BiswasRanju Kharel Sitaula

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