Further evidence of the role of cyclic AMP as a mediator of the depressant effects of beta-adrenoceptor agonists and phosphodiesterase inhibitors on slow-contracting mammalian skeletal muscles

Clinical and Experimental Pharmacology & Physiology
Z MericanB A Khalid

Abstract

The depressant effects of beta-adrenoceptor agonists and phosphodiesterase inhibitors on contractions of slow-contracting mammalian skeletal muscles are associated with increased muscular cyclic AMP levels. A strong correlation was found to exist between the percentage depression of contraction and the percentage increase in cyclic AMP level, irrespective of the drug used and regardless of the mechanism of cyclic AMP production. The results strongly support the mediatory role of cyclic AMP in the depressant effects of beta-adrenoceptor agonists and phosphodiesterase inhibitors on slow-contracting mammalian skeletal muscle contractions.

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·W C BOWMAN, M W Nott
Jul 13, 1970·Biochemical and Biophysical Research Communications·L TrinerG G Nahas
Apr 1, 1970·The Journal of Physiology·C D Marsden, J C Meadows
Jan 1, 1984·British Journal of Pharmacology·I W Rodger, M Shahid

Related Concepts

Cyclic AMP, (R)-Isomer
Adrenergic beta-Agonists
Metazoa
Felis catus
Novodrin
Inotropism
Muscle
Pavatym
Phosphodiesterase Inhibitors
Terbutalin von ct

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.