PMID: 6169631Jan 1, 1981Paper

Further evidence that carbohydrates are the immunodeterminant structures of blood group M and N specificities

Immunological Communications
G F Springer, H Tegtmeyer

Abstract

Terminal beta-D-galactopyranosyl (Gal) groups are implied in blood group N but not M specificity by the following findings: (a) Rabbit anti-asialoganglioside sera specific for terminal beta-Gal-(1 leads to 3)-GalNac agglutinate human group 0 M and N erythrocytes, the latter to a significantly higher titer, while rabbit anti-ganglioside GMl sera, whereas sialic acid modifies the antibody specificity, do not. The agglutination score with N erythrocytes was about twice that with M red blood cells. The asialoganglioside antibodies were readily absorbed by group 0 N erythrocytes, which were up to 10 times more efficient than group 0 M erythrocytes. Erythrocyte agglutination by the anti-asialoganglioside sera was inhibited by M and N antigen preparations isolated from group 0 red cells ghosts. N antigen was a better inhibitor. Asialoganglioside effectively inhibited the red cell agglutinations by anti-asialoganglioside serum. Ganglioside GMl did not inhibit. (b) Horse anti-pneumococcus Type XIV serum, which has anti-beta-Gal specificity, precipitated highly active N but not M substances. This precipitation was specifically inhibitable by oligosaccharides with terminal beta-Gal. (c) Beta galactosidase specifically inactivated native N...Continue Reading

References

Aug 1, 1975·Immunochemistry·J Kirschbaum, G F Springer
Oct 1, 1976·Die Naturwissenschaften·G F Springer, P R Desai
Jul 1, 1977·Die Naturwissenschaften·G F SpringerI Y Huang
Jun 1, 1979·Molecular Immunology·W EbertH Weicker
May 23, 1976·Biochemical and Biophysical Research Communications·K WaśniowskaE Lisowska
Mar 1, 1975·Carbohydrate Research·G F Springer, P R Desai
Nov 27, 1974·Biochemical and Biophysical Research Communications·G F Springer, P R Desai
Mar 1, 1973·Archives of Biochemistry and Biophysics·J P SegrestV T Marchesi
Jul 1, 1969·The Journal of Clinical Investigation·G F Springer, R E Horton
Feb 13, 1970·Annals of the New York Academy of Sciences·F Karush
Oct 1, 1966·Biochemistry·G F SpringerH Tegtmeyer
Feb 13, 1970·Annals of the New York Academy of Sciences·E A Kabat
Dec 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·K O Lloyd, E A Kabat
Jan 1, 1969·British Medical Bulletin·W T Morgan, W M Watkins
Apr 30, 1928·The Journal of Experimental Medicine·K Landsteiner, P Levine

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