Further exploration of the Penh parameter

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Morton Lomask

Abstract

Unrestrained plethysmography (UP) has been widely used to measure airway reactivity in conscious mice. It is non-invasive, easy to use, suitable for longitudinal studies, and allows a large throughput of animals for screening purposes. A non-dimensional parameter based on a characteristic change in the expiratory waveshape of the UP box signal, Penh, has been used as an indicator of bronchconstriction. Hamelmann et al. [Non-invasive measurement of airway responsiveness in allergen mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766-77] presented experimental data showing a correlation between Penh and intrapleural pressure, as well as lung resistance; and Dohi et al. [Non-invasive system for evaluating the allergen-specific airway response in a murine model of asthma. Lab Invest 1999;79:1559-71] showed that Penh tracked the bronchial response to allergen challenge. More recently, papers and letters to the editor have argued against the use of UP and Penh in resistance applications, presenting mathematical and theoretical arguments that the UP waveform, and parameters derived from it (Penh) are dominated by conditioning, and are essentially unrelated to resistance [Lundblad et al. A reevaluation of the ...Continue Reading

References

Jan 1, 1980·International Archives of Allergy and Applied Immunology·W A CainJ H Wells
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·E HamelmannE W Gelfand
Sep 19, 1998·Journal of Pharmacological and Toxicological Methods·B T ChongR G Townley
Sep 18, 2002·Journal of Applied Physiology·Lennart K A LundbladJason H T Bates
Jan 18, 2003·Journal of Applied Physiology·Wayne Mitzner, Clarke Tankersley
Feb 7, 2003·Journal of Applied Physiology·Thierry D FlandreDaniel J-M Desmecht
Aug 20, 2004·American Journal of Respiratory Cell and Molecular Biology·Jason BatesPeter Sly
Jan 29, 2005·Journal of Applied Physiology·Stephen J Lai-Fook, Yih-Loong Lai

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Citations

Oct 3, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yu-long LuoWei-wei Su
Apr 18, 2007·Current Allergy and Asthma Reports·James G Wagner, Jack R Harkema
Apr 10, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert G TownleyPeter Abel
Oct 31, 2007·Antimicrobial Agents and Chemotherapy·Céline DeffrasnesGuy Boivin
Nov 21, 2008·Journal of Virology·Irena Kukavica-IbruljGuy Boivin
Nov 26, 2008·American Journal of Respiratory and Critical Care Medicine·Khalil KarimiPaul Forsythe
Jul 21, 2007·American Journal of Respiratory Cell and Molecular Biology·Rodolfo P VieiraMarisa Dolhnikoff
Apr 7, 2009·American Journal of Respiratory Cell and Molecular Biology·Jeroen A J VanoirbeekWim Janssens
Jan 14, 2012·Endocrine Reviews·Elizabeth A TownsendY S Prakash
Dec 18, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mai K ElmallahDavid D Fuller
Oct 3, 2014·Mediators of Inflammation·Luana S OrtolanSabrina Epiphanio
Aug 28, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ya-nan LiHuan-ji Cheng
Nov 9, 2011·Respiratory Physiology & Neurobiology·J MooreH J Bell
Aug 2, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jiyoun KimDaniel G Remick
Jun 4, 2011·Pharmacology & Therapeutics·Jeffrey S Reynolds, David G Frazer
Aug 21, 2010·The American Journal of Pathology·Louis J VaickusDaniel G Remick
Apr 13, 2010·Respiratory Physiology & Neurobiology·Harold J Bell, Philippe Haouzi
Mar 30, 2010·Pulmonary Pharmacology & Therapeutics·Sofia Fernandez-RodriguezEmma J Kidd
Mar 12, 2010·Journal of Pharmacological and Toxicological Methods·Lorna C EwartJean-Pierre Valentin
Oct 13, 2009·Pharmacology & Therapeutics·Julie Nasra, Maria G Belvisi
Mar 2, 2011·Pediatric Pulmonology·Denise S CarnieliThais Mauad
May 8, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Mark D Inman
Apr 6, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Armin Braun, Thomas Tschernig
Oct 18, 2011·Respiratory Physiology & Neurobiology·Elena OleaConstancio Gonzalez
Jul 21, 2009·Journal of Pharmacological and Toxicological Methods·Annie DelaunoisMichel Guyaux
Nov 22, 2011·The Veterinary Journal·J ManensC Clercx

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