PMID: 5259764Jul 1, 1969Paper

Further extracellular Darwinian experiments with replicating RNA molecules: diverse variants isolated under different selective conditions

Proceedings of the National Academy of Sciences of the United States of America
R Levisohn, S Spiegelman

Abstract

Experiments are described which demonstrate that it is possible to isolate in vitro a variety of mutant RNA molecules which exhibit qualitatively distinguishable phenotypes. The results suggest that precellular evolution could have involved selective forces of previously unsuspected diversity and subtlety. Suitable adjustment of the selective conditions leads to the isolation of variants optimally designed to compete successfully with the original viral nucleic acid. One of the properties that can be built into the variants is resistance to the presence of inhibitory analogues of the normal riboside triphosphates. Potentially, such variants could be used as antiviral devices in conjunction with the more usual chemotherapeutic agents.

References

Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·I Haruna, S Spiegelman
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·N R Pace, S Spiegelman
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·D R MillsS Spiegelman
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R Levisohn, S Spiegelman
Sep 1, 1965·Journal of Molecular Biology·F SangerB G Barrell
Jun 28, 1967·Journal of Molecular Biology·D H BishopS Spiegelman

❮ Previous
Next ❯

Citations

Jul 7, 2005·Journal of Molecular Evolution·Glenn C Johns, Gerald F Joyce
Aug 1, 1971·Quarterly Reviews of Biophysics·S Spiegelman
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D L KacianS Spiegelman
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D R MillsS Speigelman
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A HuynenW Fontana
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·J A EstebanM Salas
Jun 30, 1997·Biophysical Chemistry·A Koltermann, U Kettling
Jun 30, 1997·Biophysical Chemistry·C K Biebricher, W C Gardiner
Oct 16, 2014·Genomics·Julian Adams, Frank Rosenzweig
Mar 18, 2016·Life·Katherine M McKenney, Juan D Alfonzo
Nov 5, 1991·Journal of Molecular Biology·A B ChetverinA V Munishkin
Dec 15, 1983·Journal of Molecular Biology·E A MieleF R Kramer
Nov 15, 1974·Journal of Molecular Biology·F R KramerS Spiegelman
Jan 1, 1993·Current Biology : CB·N Lehman, G F Joyce
Sep 1, 1972·Virology·A Dingjan-VersteeghE M Jaspars
Apr 23, 2008·Current Protocols in Nucleic Acid Chemistry·S D Jhaveri, A D Ellington
Jul 20, 2007·Angewandte Chemie·Gerald F Joyce
Mar 5, 2010·Current Protocols in Nucleic Acid Chemistry·Vlad CodreaAndrew Ellington
Mar 5, 2010·Current Protocols in Nucleic Acid Chemistry·Bradley HallAndrew D Ellington
Mar 5, 2010·Current Protocols in Nucleic Acid Chemistry·Carolina Díaz Arenas, Niles Lehman
Feb 12, 2008·Current Protocols in Molecular Biology·S D Jhaveri, A D Ellington
Oct 10, 2009·Current Protocols in Molecular Biology·Bradley HallAndrew D Ellington
May 1, 2013·AIChE Journal·Ryan E CobbHuimin Zhao
Jul 11, 2020·Advanced Biosystems·Kristian Le VayHannes Mutschler
Jul 24, 2021·Chemical Reviews·Yajie WangHuimin Zhao
Jun 1, 1973·Science·D R MillsS Spiegelman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
R Levisohn, S Spiegelman
Proceedings of the National Academy of Sciences of the United States of America
D R MillsS Spiegelman
ACS Synthetic Biology
Sergio G Peisajovich
© 2021 Meta ULC. All rights reserved