Further increase in the expression of activation markers on monocyte-derived dendritic cells in coronary artery disease patients with ectasia compared to patients with coronary artery disease alone.

Mediators of Inflammation
Nesligul YildirimMustafa Aydin

Abstract

Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coronary arteries. There are scarce data about the role of dendritic cells in CAE development. In this study we investigated the activation markers on the surface of monocyte-derived dendritic cells (mDCs) in coronary artery disease (CAD) patients with or without CAE. The study consisted of 6 patients who had obstructive CAD with CAE, 6 CAD patients without CAE and 6 subjects with angiographically normal coronary arteries. mDCs were cultivated from peripheral blood monocytes. Surface activation markers were detected by flow cytometry. CAD patients with CAE were detected to have significantly higher mean fluorescence intensities of CD11b, CD11c, CD54 , CD83, CD86 and MHC Class II molecules on mDCs in comparison to CAD patients without CAE and normal controls (P < .001 for all). A significant positive correlation was found between the number of vessels with CAE and the levels of CD11c, CD86, and MHC Class II molecules. mDCs display an increased cell surface concentration of activation molecules in CAD patients with CAE compared to patients with CAD alone. DC activation may play an important role for CAE development in patients with CAD.

References

Apr 1, 1978·British Heart Journal·R H SwantonB T Williams
Jan 1, 1983·Circulation·P S SwayeA J Gosselin
May 1, 1995·Cardiovascular Research·Y V Bobryshev, R S Lord
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T FreestoneJ T Powell
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·L J Zhou, T F Tedder
Nov 14, 1997·Nature Medicine·S Rowland-Jones
Nov 21, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G WickQ Xu
Dec 10, 1999·Rheumatology·C G Barnes, H Yazici
Dec 10, 1999·Rheumatology·P S Helliwell, J Hetthen
Sep 21, 2000·Immunology Letters·M Nouri-ShiraziK Palucka
Apr 17, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·G MillonigG Wick
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael WeisJohn P Cooke
Jul 8, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Masatoshi ShimizuTetsuya Nakamura
Aug 13, 2004·Atherosclerosis·Atilla YilmazChristoph D Garlichs
Nov 9, 2004·Acta Cardiologica·Lale TokgozogluYesim Hoscan
Nov 25, 2004·International Journal of Cardiology·Sharma RanjitTian Yuan
Sep 20, 2005·EMBO Reports·Marita Overhoff, Georg Sczakiel
Dec 17, 2005·Journal of Zhejiang University. Science. B·Ling-ling TangKe-zhou Liu
Jan 3, 2006·Journal of Leukocyte Biology·Atilla YilmazChristoph D Garlichs
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang Hu, Lionel B Ivashkiv

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
FCS
flow cytometry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.