PMID: 9184790May 1, 1997Paper

Further investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysema

Experimental Lung Research
J O CantorG M Turino

Abstract

Previously, this laboratory has shown that intratracheally administered hyaluronic acid (HA) significantly reduces air-space enlargement in a hamster model of emphysema induced with pancreatic elastase. Whereas HA was given immediately following elastase in those initial studies, the current investigation determined the effect of instilling HA up to 2 h before or after intratracheal administration of elastase to hamsters. Both 1 and 2 mg HA, given 2 h before pancreatic elastase, significantly decreased (p < .05) air-space enlargement compared to controls (as measured by the mean linear intercept). Instillment of 2 mg HA, 1 h after pancreatic elastase, had a similar effect (p < .05). In contrast, 1 mg HA, given 1 or 2 h after pancreatic elastase, did not significantly affect the mean linear intercept. Against human neutrophil elastase, HA exhibited the same protective effect. While neutrophil elastase induced less air-space enlargement than pancreatic elastase, both 1 and 4 mg of HA, given 2 h prior to the enzyme, still produced a significant reduction (p < .05) in the mean linear intercept. HA exerted this effect despite the fact that it initiates a transient influx of neutrophils into the lung. Since HA does not slow the clear...Continue Reading

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Citations

Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·J O CantorG M Turino
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·X J ChenG A Johnson
Sep 30, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Pei-ming HuangCharles A Hales
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Gerard M Turino, Jerome O Cantor
May 11, 2006·Experimental Lung Research·Priya P NadkarniJerome O Cantor
Apr 13, 2000·Connective Tissue Research·J O CantorG M Turino
Oct 9, 2015·International Journal of Cell Biology·Mark E LauerMark A Aronica
Apr 12, 2015·Respiratory Medicine·Jerome CantorGerard Turino
Aug 1, 1997·Nature Medicine·J Cantor
Feb 21, 2018·Annals of the American Thoracic Society·Gerard M Turino
Apr 4, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sada BoodooMaureen R Horton
Jan 30, 2002·Experimental Biology and Medicine·Jerome O CantorGerard M Turino
Dec 29, 2005·Experimental Biology and Medicine·Jerome O CantorGerard M Turino
Oct 3, 2020·Cells·Luis Máiz Carro, Miguel A Martínez-García
Aug 29, 2020·American Journal of Respiratory Cell and Molecular Biology·Sara J Bonvini
Nov 20, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Meropi KarakioulakiDaiana Stolz

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