Aug 1, 1989

Further investigation on the high-conductance ion channel of the inner membrane of mitochondria

Journal of Bioenergetics and Biomembranes
M C SorgatoW Stuehmer


By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.

  • References27
  • Citations25


Mentioned in this Paper

Membrane Fraction
Resting Potentials
Mitochondria, Heart
PDZK1 gene
Electric Conductivity
Ion Channel
Clamping Activity
Intracellular Membranes

About this Paper

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