PMID: 6163086Mar 12, 1981Paper

Further molecular complexities of H-2 K- and D-region antigens

Nature
P Démant, D Iványi

Abstract

The K and D regions of the H-2 gene complex are highly polymorphic and control cell-surface structures involved in the H-2 restriction of cytotoxic T lymphocytes. Originally it was assumed that each of these regions controlled only one type of antigenic molecule, H-2K and H-2D, respectively. The finding that the D region controls H-2L and H-2M, as well as H-2D, molecules suggests that the system of H-2 antigens is more complicated. We demonstrate here previously unknown H-2 molecules detected by anti-K- and D-region alloantisera in co-capping experiments. Three different types of molecule, distinct from Ia and Qa antigens, are distinguished in the products of the Ddx region, and two in the products of the Dk and Kd regions. Analysis of the antigenic heterogeneity of K- and D-region products may further understanding of the function of these regions in cell-mediated immunity.

References

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Citations

Jan 1, 1981·Immunogenetics·P DémantK Fischer-Lindahl
Jan 1, 1986·Immunogenetics·B W DucemanF C Grumet
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J L LalanneP Kourilsky
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M TryphonasP P Jones
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R J RubockiD R Lee
Jan 1, 1981·Immunological Reviews·H Festenstein, W Schmidt
Jan 1, 1981·Immunological Reviews·P DémantM H Roos
Jan 1, 1983·Tissue Antigens·F FigueroaJ Klein
Feb 1, 1983·European Journal of Immunology·G I EvanL Croft

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