PMID: 11908968Mar 23, 2002Paper

Further new staurosporine derivatives from the ascidian Eudistoma toealensis and its predatory flatworm Pseudoceros sp

Journal of Natural Products
P SchuppVictor Wray

Abstract

Three new indolocarbazole alkaloids, 3-hydroxy-4'-N-methylstaurosporine (3), 3-hydroxy-4'-N-demethylstaurosporine (4), and 3'-demethoxy-3'-hydroxy-4'-N-demethylstaurosporine (5), were isolated from the marine ascidian Eudistoma toealensis and its predatory flatworm Pseudoceros sp. in addition to two known staurosporines. The structures were determined by 1D and 2D homonuclear and 1H-detected heteronuclear NMR spectroscopy and from comparisons with published data. CD measurements for these five staurosporine derivatives, as well as the previously described seven staurosporines, are reported, confirming that all derivatives possess the 2'S,3'R,4'R,6'R configuration.

Citations

Apr 7, 2012·Chemical Reviews·Arndt W SchmidtHans-Joachim Knölker
Nov 23, 2006·Natural Product Reports·César SánchezJosé A Salas
Apr 15, 2010·Marine Drugs·Sheila Marie Pimentel-ElardoUte Hentschel
Jan 18, 2017·Natural Products and Bioprospecting·Satheesh Kumar PalanisamyAngela Marino
Oct 26, 2018·The Journal of Antibiotics·Appadurai Muthamil IniyanSamuel Gnana Prakash Vincent
Dec 24, 2011·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 24, 2019·Cell Stress & Chaperones·Andrey Victorovich BorodaNelly Adolphovna Odintsova
Feb 14, 2015·Marine Biotechnology·Georg SteinertPeter J Schupp
Nov 4, 2020·Planta medica·Diego V WilkeLeticia V Costa-Lotufo
Jan 27, 2021·Marine Drugs·Justin M McNabJane E Williamson
Dec 10, 2020·Marine Drugs·Marilia BarrecaFrancesco Bertoni
Jan 25, 2003·Journal of Natural Products·Chang-Yun WangRainer Ebel
Mar 1, 2003·Journal of Natural Products·Peter SchuppPeter Proksch
Dec 29, 2004·Journal of Natural Products·Suwigarn PedpradabPeter Proksch
May 20, 2008·Journal of Natural Products·Fernando ReyesCarmen Cuevas

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