May 1, 1976

Further observations on the potentiation of the antibacterial effect of methenamine by acetohydroxamic acid

The Journal of Infectious Diseases
D M MusherG B Templeton

Abstract

The use of methenamine in the treatment of urinary tract infections due to Proteus species is limited by urine alkalinity. Acetohydroxamic acid, an inhibitor of urease, maintains acidity despite growth of Proteus in urine. Easily achievable concentrations of acetohydroxamic acid in vitro systems that simulated the dynamics of the urinary tract potentiated the antibacterial effect of methenamine against Proteus species. The combined use of a urease inhibitor and methenamine may be effective in the treatment of urinary infection caused by these organisms.

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Mentioned in this Paper

Urine
Urotropin
Hydroxamic Acids
Urease Inhibitor [EPC]
Proteus Syndrome
Urinary Tract Infection
Inhibitors
Proteus
Etiology
Entire Urinary Tract

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