Further results of the MRC treatment trial for mild hypertension

Nephron
W E MiallP Brennan

Abstract

17,354 mildly hypertensive adults with diastolic (v) pressures of 90-109 mm Hg took part in a 5 1/2 year trial in which each was randomized to treatment with either bendrofluazide, propranolol, or placebo. The main results of the trial have been published; they showed stroke benefit but no overall reduction in the incidence of coronary events and no effect on all-cause mortality. Further analyses of the data have shown interesting differences between subgroups of the population, with regard to the effects of the two types of treatment on stroke, on coronary events and on ECG changes. These results, and the effects of interaction between cigarette smoking and the efficacy of these drugs, if confirmed in other studies, should influence the choice of drug therapy for mild hypertension.

Citations

Jan 1, 1990·Cardiovascular Drugs and Therapy·J I Robertson
Apr 1, 1996·Clinical and Experimental Hypertension : CHE·A W Hoes, D E Grobbee
Sep 17, 1988·BMJ : British Medical Journal
Apr 19, 2018·The Cochrane Database of Systematic Reviews·James M WrightRupam Gill
Jun 6, 2019·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Jul 10, 2009·The Cochrane Database of Systematic Reviews·James M Wright, Vijaya M Musini
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Diana DiaoFrancois Gueyffier

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