PMID: 8981350Jan 1, 1996Paper

Further search for small molecular inactivants capable of eliciting respiratory mucosal immunogenicity by modifying Sendai virus core RNA

Microbiology and Immunology
T Miyamae

Abstract

Five groups of 32 chemicals were examined regarding their immunological functions as modifier inactivants to make inactivated Sendai nasal vaccine using a contact exposure experiment, direct immunofluorescent method, and serum HI titer. (1) Five of the nine reactive groups of reactive dyes (2-chloropyridine, 2, 4, 6-trichloropyrimidine, vinylsulfonic acid, epichlorohydrin and beta-chloroethylamine) induced complete or almost complete defense in the entire respiratory tract, and the four other vaccines brought about slight infection in the respiratory tracts. There was no marked rise in serum HI titers post-exposure, despite uneven development. (2) Of the four sizable substituted AS naphthol vaccines, naphthol AS-IRG and AS-G vaccines elicited nearly complete defense, but the two other vaccines, inactivated with more elongated molecules, invited rare and successive infections. The three immune groups produced invariably high serum HI titers. (3) Of the six naphthalene derivative vaccines, two (3-hydroxy-2-naphthoic acid methylester and 2-naphthol-6-sulfonic acid) induced complete or almost complete protection. But two vaccines brought about less protection, and the remaining two vaccines caused heavy infections. (4) Of the six b...Continue Reading

References

Dec 1, 1987·Nihon juigaku zasshi. The Japanese journal of veterinary science·T Miyamae
Feb 24, 1968·Nature·K Raska, E P Cohen
Aug 1, 1994·American Journal of Respiratory Cell and Molecular Biology·X Y YuE W Spannhake
Apr 1, 1993·The American Review of Respiratory Disease·A J CoyleC G Irvin

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Citations

Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Yan-Ling ZhouMin Zhao
Jan 30, 2007·Ultrasonics Sonochemistry·Todor DeligeorgievJulio Alvarez-Builla
Mar 6, 2018·Acta Crystallographica. Section C, Structural Chemistry·Dorota PogodaVeneta Videnova-Adrabinska
Sep 29, 2020·Nature Reviews. Chemistry·Willem A Velema, Eric T Kool

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