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Further studies of metyrapone effects upon anilide hydroxylation

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

K C Leibman, Erick Ortiz

PMID: 1226

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Abstract

The enhancing effect of metyrapone upon the p-hydroxylation of acetanilide has been confirmed with the use of a new gas-chromatographic method for the determination of acetaminophen. This effect has been shown not to be due to inhibition of hydrolysis of acetaminophen or interference wi...read more

Mentioned in this Paper

Acetophenone
Sulfonamide Anti-Infective Agents
Phenols
SU 4885
Hydroxylation
Metyrapone
Acetanilide
Phenol
2,2'-Dipyridyl
Metabolic Inhibition
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  • Further studies of metyrapone effects upon anilide hydroxylation

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    K C Leibman, Erick Ortiz

    PMID: 1226

    DOI:

    Abstract

    The enhancing effect of metyrapone upon the p-hydroxylation of acetanilide has been confirmed with the use of a new gas-chromatographic method for the determination of acetaminophen. This effect has been shown not to be due to inhibition of hydrolysis of acetaminophen or interference wi...read more

    Mentioned in this Paper

    Acetophenone
    Sulfonamide Anti-Infective Agents
    Phenols
    SU 4885
    Hydroxylation

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