May 1, 1976

Further studies of the physical and metabolic properties of foot-and-mouth disease virus temperature-sensitive mutants

Infection and Immunity
J Y Richmond, J Polatnick

Abstract

Three temperature-sensitive (ts) mutants of foot-and-mouth disease virus were classified as ribonucleic acid negative and as belonging to the same complementation group when measured by virus yields and [3H] uridine incorporation in paired, mixed infections at the nonpermissive temperature (38.5C). Mutant ts-22, the only mutant able to produce plaques at 38.5 C, was more sensitive to acid than were the parental wild-type or other mutant viruses. Diethylaminoethyl-dextran did not enhance the plaque-forming ability of the mutant viruses at 38.5C. All of the viruses inhibited host cell protein syntehsis at both permissive (33C) and nonpermissive (38.5C) temperatures.

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Mentioned in this Paper

Metabolic Process, Cellular
Aphthovirus
Coinfection
Bacteriophage Plaque Assay
Foot-and-Mouth Disease
Pulsar
Dental Plaque
Senile Plaques
Mutant
RNA, Viral

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