Further studies on mechanisms regulating the voiding cycle of the rat urinary bladder

General Pharmacology
C A MaggiA Meli

Abstract

1. The effect of transection of pudendal or hypogastric nerves and of various pharmacological pretreatments on the bladder voiding cycle elicited by saline filling was investigated in urethane-anesthetized rats. 2. Sectioning of pudendal nerves reduced efficiency of the expulsive phase of the voiding cycle while sectioning of hypogastric nerves enhanced voiding efficiency and reduced residual volume. 3. An increased voiding efficiency was also observed in 6-hydroxydopamine-treated rats. 4. Atropine and physostigmine decreased and increased voiding efficiency, respectively. Indomethacin pretreatment produced a marked increase in residual volume. 5. These findings indicate that the autonomic innervation of the bladder and urethra as well as production of local factors such as prostanoids regulates not only the collecting phase of the cystometragram but also influence markedly voiding efficiency.

References

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Citations

May 4, 2012·American Journal of Physiology. Renal Physiology·H Sandeep PrakasamGerard Apodaca
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Jun 27, 2008·Brain Research·César Feliciano PastelínYolanda Cruz
Oct 24, 2014·American Journal of Physiology. Renal Physiology·Yolanda CruzMargot S Damaser
Oct 12, 1999·The American Journal of Physiology·K B Thor, M A Muhlhauser
Jul 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yolanda Cruz, John W Downie
Dec 8, 2020·American Journal of Physiology. Renal Physiology·James A HokansonWarren M Grill

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