PMID: 2492429Jan 1, 1989Paper

Further studies on post-antibiotic effect and synergism in two strains of Streptococcus faecalis

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
K Fuursted

Abstract

The differences in the synergistic potential for either killing effect or increase in duration of post-antibiotic effect (PAE) seen with various beta-lactam-aminoglycoside combinations in two strains of Streptococcus faecalis were further studied to examine this relationship in more detail. It was seen that a strain which produced a synergistic increase in recovery period (PAE greater than or equal to 0.5 h), comparing the beta-lactam antibiotics alone and when combined with streptomycin, showed increased sensitivity (greater than or equal to 1 log10 reduction in viable counts) to a subinhibitory concentration of streptomycin added to a culture recovering from the PAE; this was not demonstrated with a strain showing no increase in PAE when briefly exposed to a combination therapy, although its corresponding killing curve was clearly synergistic. Moreover, it was seen that the differences in the synergistic prolongation of recovery period when combining various aminoglycosides at 1/4 x MIC with ampicillin were consistent with the different duration of PAE with the particular aminoglycoside alone at the MIC.

Citations

Apr 1, 1992·Annals of Neurology·W R TyorD E Griffin
Apr 1, 1997·Immunological Reviews·G F BurtonA K Szakal
Oct 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A M Bergholm, K Dornbusch
Jan 1, 1997·Annual Review of Immunology·H StoiberM P Dierich
Apr 6, 1999·APMIS. Supplementum·K Fuursted

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