PMID: 2124604Oct 1, 1990Paper

Further studies on protective effects of vitamins in cyclophosphamide-induced cleft palate

International Journal of Oral and Maxillofacial Surgery
M Dostal, Johannes Schubert

Abstract

The effects of vitamins B1, B6, and E administered 1 day before and simultaneously with an embryotoxic dose of cyclophosphamide (CPM) were studied using random-bred mice ICR (VELAZ). A single dose of 20 mg/kg CPM administered i.p. or i.m. on day 12 of pregnancy induced in the foetuses cleft palate and malformations of the upper and lower limbs. Both vitamins B1 and B6 decreased nonsignificantly the overall proportion of malformed foetuses and changed the spectrum of malformations, the decrease in foetuses with malformed upper limbs being statistically significant. In the groups supplemented with vitamins the mean foetal weight was higher in litters without malformed upper limbs than in litters with malformed upper limbs and those of both types in the control group. Similar effects of vitamin E were statistically nonsignificant. It is most likely that vitamins influence the pharmacokinetics of cyclophosphamide or its metabolites. The data provided offer no explanation for the claimed beneficial effects of vitamins for preventing the occurrence of orofacial clefts in patients at risk.

References

Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G Millicovsky, M C Johnston
Dec 1, 1982·Teratology·T Yoneda, R M Pratt

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Citations

Jan 20, 2004·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Edward SyskaJohannes Schubert
Oct 30, 2001·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·S G Gong, R L Eulenberg
Mar 19, 1999·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·F A MalekJ Fanghänel
May 7, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Konstanze SchellerJohannes Schubert
Oct 4, 2002·International Journal of Oral and Maxillofacial Surgery·J SchubertE Syska
Nov 1, 1990·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·J SchubertH W Raupach
Aug 31, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Terence R S Ozolins
Oct 1, 1996·European Journal of Oral Sciences·C Jacobsson, G Granström
Mar 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·C Jacobsson, G Granström
Mar 2, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Hakan AyNedim Unal

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