PMID: 1247607Feb 16, 1976

Further studies on the effect of phosphoenolpyruvate on respiration-dependent calcium transport by rat heart mitochondria

Biochimica Et Biophysica Acta
P Chudapongse


Phosphoenolpyruvate was found to depress extra oxygen consumption associated with Ca2+ -induced respiratory jump by rat heart mitochondria. Addition of phosphoenolpyruvate to mitochondria which have accumulated Ca2+ in the presence of glutamate and inorganic phosphate causes the release of Ca2+ from mitochondria. The phosphoenolpyruvate-stimulated Ca2+ efflux can be observed with mitochondria loaded with low initial Ca2+ concentration (0.12 mM) in the incubation medium. Measurements of mitochondrial H+ translocation produced by addition of Ca2+ to respiring mitochondria show that phosphoenolpyruvate depresses H+ ejection and enhances H+ uptake by mitochondria. The Ca2+ -releasing effect of phosphoenolpyruvate was found to be significantly stronger than that produced by rotenone when added to mitochondria loaded with Ca2+ in the presence of glutamate and inorganic phosphate. Dithiothreitol cannot overcome the effect of phosphoenolpyruvate on mitochondrial Ca2+ transport.


Apr 1, 1964·Biochemistry·W W CLELAND
Oct 1, 1964·The Journal of Cell Biology·J W GREENAWALTA L Lehninger


Jan 1, 1980·Progress in Biophysics and Molecular Biology·P V Sulakhe, P J St Louis
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A L LehningerE A Bababunmi
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H R LötscherC Richter
Feb 1, 1978·Biological Reviews of the Cambridge Philosophical Society·F L Bygrave
Jul 24, 2010·Neurochemical Research·Angela Saito, Roger F Castilho
Jul 10, 2012·Neuroscience and Biobehavioral Reviews·Yan SaiZhaojun Dong
Mar 1, 1979·The Journal of Experimental Zoology·H G Shertzer, J Cascarano

Related Concepts

Mitochondria, Muscle
Oxygen Consumption
Rats, Laboratory

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