PMID: 8583353Oct 1, 1995Paper

Further studies on the ex-vivo effects of procarbazine and monomethylhydrazine on rat semicarbazide-sensitive amine oxidase and monoamine oxidase activities

The Journal of Pharmacy and Pharmacology
A Holt, B A Callingham

Abstract

Following administration of the anticancer agent, procarbazine, or one of its metabolites, monomethylhydrazine, to rats, activities of monoamine oxidases A and B (MAO A and MAO B) and of semicarbazide-sensitive amine oxidase (SSAO) were measured ex-vivo. Both compounds were found to be potent inhibitors of SSAO in tissue homogenates, exhibiting ID50 values in most tissues of approximately 8 mg kg-1 (procarbazine) and 0.08 mg kg-1 (monomethylhydrazine). Concurrent dose-dependent inhibition of MAO activities did not occur. However, in liver, potentiation of MAO B activity, to 140% of that in controls, was apparent following monomethyl-hydrazine and this effect was independent of the drug dose. Both compounds produced a dose-dependent potentiation of MAO A in brown adipose tissue, the elevation being more pronounced following monomethylhydrazine, with activity rising to 350% of that in control homogenates. In a parallel in-vitro study, monomethylhydrazine was without effect on MAO A in brown adipose tissue homogenates. By perfusing the SSAO substrate, benzylamine, through the isolated mesenteric arterial bed of the rat, it was found that pretreatment of animals with procarbazine or monomethylhydrazine reduced metabolism of this am...Continue Reading

References

Jun 1, 1992·The Journal of Pharmacy and Pharmacology·A HoltR Kettler
Jun 1, 1992·The Journal of Pharmacy and Pharmacology·A HoltB A Callingham
Feb 1, 1991·Biochemical Society Transactions·B A CallinghamJ Elliott
Oct 1, 1989·British Journal of Pharmacology·J ElliottD F Sharman
Jan 1, 1988·Free Radical Research Communications·G R HaenenA Bast
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Jan 1, 1994·Annual Review of Biochemistry·J P Klinman, D Mu

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Citations

Oct 17, 1998·Journal of Psychosomatic Research·D J Newport, C B Nemeroff
Dec 31, 2003·Neurotoxicology·Jeff O'SullivanKeith F Tipton
Sep 17, 2013·Psycho-oncology·Shawna L KraftJolene R Bostwick
Mar 18, 1999·Toxicology and Applied Pharmacology·S D LangfordP J Boor

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