Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats

Natural Product Research
Zhen-Ming LuZheng-Hong Xu

Abstract

To further understand the hepatoprotective activity of Antrodia camphorata in living systems and the possible mechanisms of this protection, the effects of fractions from A. camphorata in submerged culture on the liver and its antioxidative system in acute ethanol intoxicated rats were investigated. The results showed that the ethanolic extract (Fr-I) of A. camphorata was the most effective in the prevention of ethanol-induced acute liver injury and free radical generation in rats. The ethanolic extract administrated prior to ethanol significantly prevented the increase in serum levels of hepatic enzyme markers such as aspartate aminotransferase and alanine aminotransferase. It also normalised the increase of hepatic malondialdehyde concentration and the decrease of glutathione levels in the liver. Moreover, Fr-I improved the ethanol-induced decrease of hepatic glutathione peroxidase and reductase activities. On the basis of these results, the ethanolic extract of A. camphorata may exert its hepatoprotective activity by up-regulating GSH-dependent enzymes and inhibiting free radical formation in the liver.

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Citations

Nov 5, 2013·Chinese Medicine·Patrick Ying-Kit YueKelvin Sze-Yin Leung
Apr 9, 2013·Pharmacology & Therapeutics·Mei-Chin LuYang-Chang Wu
Apr 5, 2016·International Journal of Molecular Sciences·Puiyan LamYibin Feng
Feb 11, 2015·Applied Microbiology and Biotechnology·Chun-Lin Lee
Oct 13, 2012·Journal of Ethnopharmacology·Ren-Bo DingJian-Bo Wan
Feb 7, 2017·The American Journal of Chinese Medicine·Chiung-Huei PengChau-Jong Wang
May 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Canrui YangJihong Huang
Feb 14, 2015·Organic Letters·Rohidas S Sulake, Chinpiao Chen

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