Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry

Experimental Eye Research
A M AvundukY Tekelioğlu

Abstract

Atopic keratoconjunctivitis (AKC) is an ocular manifestation of systemic hypersensitivity. Although the pathogenesis of AKC is not fully understood, some previous data suggest that a decrease in numbers of suppressor T lymphocyte (Ts) and increase of Th, especially Th2 (the second subgroup of helper T lymphocyte), at the ocular surface may play an important role in the occurrence of the disease. In this study, the percentages of naive-Th (CD4/45RA+) and memory-Th (CD4/29+) cells, and the Th/Ts and memory-Th cells/naive-Th cells ratios were measured in the blood and tear samples of patients with AKC, atopic patients without ocular involvement and normal volunteers, using flow cytometry. Groups were compared using the Mann-Whitney U test. We found that patients with AKC had significantly higher memory-Th cell concentration, and Th/Ts and memory-Th cells/naive-Th cell ratios both in the tear and blood samples compared to normal subjects. While no significant difference existed between the tear samples of the atopic patients without ocular involvement and normal volunteers with respect to the above values, atopic patients had higher percentages of memory-Th cells and higher Th/Ts and memory-Th cells/naive-Th ratios in their blood t...Continue Reading

References

Feb 1, 1992·Ophthalmology·S J TuftR J Buckley
Aug 1, 1991·Ophthalmology·C S FosterJ E Dutt
Feb 1, 1991·Ophthalmology·S J TuftR J Buckley
May 1, 1985·Clinical Immunology and Immunopathology·Z HemadyR E Rocklin
Jan 1, 1983·The Journal of Allergy and Clinical Immunology·D Y LeungR S Geha
Jun 1, 1981·The Journal of Allergy and Clinical Immunology·D Y LeungR S Geha
Aug 1, 1995·Drugs·M Hingorani, S Lightman

❮ Previous
Next ❯

Citations

Jul 31, 2010·Immunology and Allergy Clinics of North America·Brett Bielory, Leonard Bielory
Dec 10, 2002·American Journal of Ophthalmology·Elisabeth M MessmerAnselm Kampik
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·L Bielory
Sep 18, 2018·Current Opinion in Ophthalmology·Nimesh PatelAnat Galor
Jan 25, 2003·International Ophthalmology Clinics·Hong ZhanSusan Lightman
May 22, 2010·European Journal of Ophthalmology·Kurt Spiteri CornishKatheravelu Ramaesh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.